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学术报告:Walking with insects: How viruses manipulate insect behaviour
发布日期:2021-04-10 浏览次数: 信息来源:植保学院 字号:[ ]

报告人VERA I.D. ROS, Laboratory of Virology, Wageningen University & Research (WUR)


报告方式:腾讯会议, 会议ID: 462 846 620




2020 – present   Tenure Track Associate Professor – Laboratory of Virology, WUR.

2015 – 2020     Tenure Track Assistant Professor – Laboratory of Virology, WUR.

2012 – 2014     VENI Postdoctoral Associate – WUR. Parasitic manipulation.

2009 – 2012     Postdoctoral Associate – WUR. Baculovirus – insect interactions.

2008 – 2009     Postdoctoral Associate – University of Pennsylvania, USA.

2004 – 2008     PhD in Biology – University of Amsterdam (UvA).

The main researches are as following:

  1. Baculovirus-induced manipulation of insect host behaviourMany parasites manipulate their host’s behaviour, in order to enhance their spread. Exquisite examples of behavioural manipulation are known, including hypermobility and pre-death climbing behaviour (tree-top disease) in baculovirus-infected caterpillars. However, the underlying molecular mechanisms are poorly understood. We aim at clarifying which parasitic genes modify host behaviour and which pathways in the host transduce the parasite-induced signal into a change in behaviour. Baculoviruses infecting caterpillars provide a unique system to tackle these questions, because baculoviruses can be easily genetically engineered in the laboratory (e.g. creating single gene knockout strains), and because these viruses are known to induce behavioural changes in caterpillars (hypermobility and climbing behaviour/tree top disease). We are currently investigating how viruses invade the insect nervous system to achieve modification of host behaviour. We have written two extensive reviews on parasitic modification of host behaviour and have published several papers in which the molecular mechanism is beginning to be unravelled.

  2. Biological control of caterpillars. Together with (UvA) I will lead a project aimed at developing 'attract and infect' strategies agains the Fall Armyworm in Africa. The Fall Armyworm (FAW) Spodoptera frugiperda, a major pest in staple crops in North and South America, recently invaded Africa (first reported in 2016), where it is currently spreading with incredible speed. Currently, control of this pest insect mainly depends on chemical insecticides. Apart from being very expensive for most small-scale African farmers, these insecticides also pose a genuine health risk, since the knowledge and equipment required for a safe application are mostly lacking. Chemical insecticides negatively affect the environment and non-target species and, in addition, resistance towards these insecticides has already been reported. Therefore, there is an urgent need for safe, sustainable, environmental friendly alternative control measures that can be easily applied in the field by local farmers. Biological control methods that are currently used to control lepidopteran insect pests include pheromone trapping (trapping male moths using female pheromones) and the spraying of baculoviruses (killing caterpillars). However, a combination of both methods has not been explored, and might yield exciting opportunities for biological control, surpassing the effectiveness of each single method. Our project aims to develop a sustainable attract-and-infect strategy for the control of the invading fall army worm in Africa.


Gasque SN, van Oers MM, Ros VID (2019). Where the baculoviruses lead, the caterpillars follow: Baculovirus-induced alterations in caterpillar behaviour. Current Opinion in Insect Science 30:30-36. Invited review paper special issue ‘Behavioural Ecology’.

Han Y, van Houte S, van Oers MM, Ros VID (2018). Timely trigger of caterpillar zombie behavior: temporal requirements for light in baculovirus-induced tree-top disease. Parasitology 145:822-827.

Han Y, van Houte S, van Oers MM, Ros VID (2018). Baculovirus PTP2 functions as a pro-apoptotic protein. Viruses 10:181.

Zhang S, An S, Hoover K, Li Z, Li X, Liu X, Shen Z, Fang H, Ros VID, Zhang Q, Liu X (2018). Host miRNAs are involved in hormonal regulation of HaSNPV-triggered climbing behavior in Helicoverpa armigera. Molecular Ecology 27:459-475.

Van Houte S, van Oers MM, Han Y, Vlak JM, Ros VID (2015). Baculovirus infection triggers a positive phototactic response in caterpillars: a response to Dobson et al. (2015). Biology Letters 11:20150633.

Han Y, van Houte S, Drees GF, van Oers MM, Ros VID (2015). Parasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in Spodoptera exigua larvae by extending the time to death. Insects 6:716-731. (Invited paper special issue ‘Parasite-Insect Interactions’).

Ros VID*, van Houte S*, Hemerik L, van Oers MM (2015). Baculovirus-induced tree-top disease: how extended is the role of egt as a gene for the extended phenotype? Molecular Ecology 24:249-258. *Contributed equally to this work.

Van Houte S, van Oers MM, Han Y, Vlak JM, Ros VID (2014). Baculovirus infection triggers a positive phototactic response in caterpillars to induce ‘tree-top’ disease. Biology Letters 10:20140680.

Van Houte S*, Ros VID*, van Oers MM (2013). Walking with insects. Molecular mechanisms behind parasitic manipulation of host behaviour. Molecular Ecology 22:3458-3475. *Contributed equally to this work.

Ros VID, Fleming V, Feil EJ, Breeuwer JAJ (2012). Diversity and recombination in Wolbachia and Cardinium from Bryobia spider mites. BMC Microbiology 12 (Suppl 1):S13.





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